Disease & mental disorder

"If we learn to see problems in terms of a general disorder of energy metabolism, we can begin to solve them" - Ray Peat

Study links and people with results maybe twitter posts for motiovation (Testimonies), spreading hope, avoiding helplesness

Progesterone, lowering inflammation, fixing defficiencies, getting your metabolic rate up fixes most things.

While treating the root cause, you can still tend to the outside, minimize symptoms to improve your life quality.

If you can't access the full study, use https://sci-hub.se/

Digestion/Gut

Protruding gut

Sibo (link)

Weak abdominal muscles/PSOAS

Visceral fat

Raised inflammation

https://x.com/RayPeatHeadShop/status/1995290567971119473

IBS

Problem	Mechanics	Solution	Dose
Abdominal pain	Low butyrate → increased visceral hypersensitivity & inflammation	Microencapsulated sodium butyrate	300 mg/day (commonly 150 mg twice per day) as used in the clinical trial IBS was improved by ~50% in 96% of patients
Bloating / gas	Impaired fermentation balance and weakened gut barrier increase luminal irritation
Irregular bowel movements (constipation/diarrhea)	SCFA deficiency alters motility and mucosal signaling
Overall IBS symptom severity	Low butyrate reduces mucosal integrity and increases inflammation
Bloating, gas, and pain	Excessive bacterial fermentation in small intestine (SIBO), leading to gas and inflammation	Raw Carrot Salad (antibacterial fiber, binds endotoxin, estrogen)	1 serving between meals
Endotoxin absorption from gut	LPS crosses gut barrier, triggers systemic inflammation and serotonin release	Activated Charcoal – binds endotoxin and serotonin precursors	500–1000 mg away from food, 2–3x/week
High serotonin in gut	Serotonin increases gut motility and sensitivity, promotes inflammation	Vitamin B6, Niacinamide, Magnesium – serotonin inhibitors and metabolism support	B6: 20–50 mg/dayNiacinamide: 100–500 mg/dayMagnesium: 200–400 mg/day

Leaky gut

https://x.com/Helios_Movement/status/1993680224077136047?

GERD/Acid reflux

Problem	Mechanics	Solution	Dose
Low stomach acid (hypochlorhydria)	Leads to poor digestion and delayed gastric emptying → fermentation → pressure on LES	Betaine HCl + pepsin (used cautiously and contextually)	300–600 mg with protein meals
Inflammation and nitric oxide excess	Inhibits mitochondrial function and lowers LES tone	Vitamin E, aspirin (low-dose)	E: 100–200 IU, aspirin: 30–80 mg
Estrogen dominance	Relaxes smooth muscle including LES	Progesterone – restores muscle tone and opposes estrogen	5–20 mg topical or oral
Stress-induced hyperventilation	Reduces CO₂, tightens diaphragm and LES dysfunction	Carbon dioxide support via breathing, bag breathing, or CO₂ baths	10–20 minutes/day
Serotonin excess	Promotes gut motility dysfunction and inflammation	Cyproheptadine, B6, magnesium	Cypro: 1–2 mg/day; B6: 25–50 mg; Mg: 200–400 mg
Endotoxin (LPS)	Irritates gut lining, slows transit, increases reflux symptoms	Activated charcoal, carrot salad, cascara	Charcoal: 500 mg before bed; Carrot: daily; Cascara: 1/4 tsp
Poor bile flow	Delayed digestion increases pressure and reflux	Taurine + glycine + choline	Taurine: 1–2 g; Glycine: 3–10 g; Choline: 250–500 mg
PUFA damage to stomach lining	Increases inflammation and oxidative stress	Saturated fats (coconut oil, butter), vitamin E	Replace PUFA; 100–200 IU E
Esophageal inflammation	Acid + endotoxin → mucosal damage	Aloe vera juice, baking soda, glycine, vitamin E	Aloe: 30–60 ml; bicarb: 1/4 tsp in water; glycine: 5 g
Dental erosion	Acid up the esophagus wears enamel	Calcium carbonate, baking soda rinse, sugar for salivation	Calcium: 250–500 mg; baking soda rinse post-meal
ENT inflammation / tinnitus	LPR (laryngopharyngeal reflux) irritates Eustachian tubes	CO₂ therapy, vitamin A, pregnenolone, reduce reflux	A: 5,000 IU; pregnenolone: 10–20 mg
Mood issues	Cortisol, low dopamine from reflux stress	Vitamin C, niacinamide, thyroid, dopamine precursors	C: 1–3 g; niacinamide: 100–300 mg

SIBO/Candida overgrowth

"A very hypothyroid person sometimes has bacteria and yeast living in the stomach." - Ray Peat

Problem	Mechanics	Solution	Dose
Hypothyroidism	Hypothyroid people are 11 times more likely to have SIBO.	Fixing thyroid or supplementing
Bloating, gas, diarrhea, constipation	Fermentation in small intestine due to slowed motility, hypothyroidism, or excess endotoxin	Thyroid (T3) – boosts motility and lowers endotoxin load	Start low, titrate up under guidance
Dysbiosis, excess fermentation	Excess bacteria producing serotonin, nitric oxide, lactate	Activated charcoal / bamboo charcoal	500–1,000 mg away from food
Excess serotonin & histamine from gut flora	Serotonin is inflammatory and slows gut motility	Vitamin B6, Niacinamide – co-factors for serotonin breakdown	B6: 10–50 mg, Niacinamide: 50–100 mg with meals
Weak gut barrier & inflammation	Endotoxin, nitric oxide, and stress hormones	Vitamin A, D, and E; Glycine (gelatin)	A: 5,000–10,000 IU; D: 1,000–2,000 IU; E: 100–400 IU; Glycine: 5–10 g/day
Antibiotic side effects or resistance	Gut flora imbalance and relapse from overuse	Herbal antimicrobials (e.g., berberine, oregano, FC-Cidal, AR-BR)	2 capsules BID, cycle 2–4 weeks
Recurrence from low stomach acid	Insufficient HCl allows bacteria into SI	Betaine HCl + Pepsin	300–600 mg with protein meals
Motility stagnation	Disrupted MMC (migrating motor complex)	Ginger, low-dose erythromycin (motilin agonist)	Ginger: 500–1,000 mg before bed
Candida overgrowth, white tongue	Thrives in high Estrogen environment	Progesterone, Camfocel
Candida thrives with low Vitamin D	Low vitamin D raises inflammation, worsens the functioning of the immune system, lowers it's killing ability.	Vitamin D	300 IU
Tooth decay (Dental hygiene)	Bacteria comes from the gut into the mouth via reverse peristalsis.	Clean your gut

https://x.com/Outdoctrination/status/1995535111320633625?t=wCBG2gUrbUfyk6dWD-5SdA&s=33

Hormonal

Allergies

"With allergies, it’s similar to autoimmunity except not so serious, estrogen changes the immune function, tends to shrink the thymus gland, and increase antibody production without the guidance of the thymus cells." - Ray Peat

Problem	Mechanics	Solution	Dose
Thymus shrinkage	Reduces T-cell production, weakening immunity and increasing autoimmunity risk. Hypothyroidism leads to elevated estrogen/cortisol which causes thymus atrophy over weeks.	Address hypothyroidism to maintain thymus function, potentially using thyroid hormone support.

Estrogen dominance

https://x.com/RayPeatHeadShop/status/1748075159490093209

Low testosterone

https://x.com/lowmegatron/status/1995583768954835439?t=vTVU5pzqUt9AKdJcKK7hZA&s=33

Metabolic

Diabetes

https://x.com/Helios_Movement/status/1994117243441934395

B vitamins/Brewer's yeast

Autoimmune

Arthritis

Problem	Mechanics	Solution	Dose
Cartilage loss	Low vitamin K1 intake impairs the activation of vitamin K-dependent proteins (e.g., matrix Gla protein), leading to increased cartilage proteoglycan loss and potential calcification, disrupting joint tissue homeostasis.	Increase dietary or supplemental vitamin K1 intake to support cartilage health and prevent degeneration.

Rheumatoid Arthritis

Problem	Mechanics	Solution	Dose
Rheumatoid arthritis triggered by specific gut bacteria causing systemic autoantibody generation and joint inflammation	Gut bacteria like Subdoligranulum strain induce immune responses, leading to migration of autoreactive cells to joints, causing cartilage and bone damage	Targeting gut dysbiosis with treatments like antibiotics or dietary adjustments to reduce bacterial overgrowth

Insulin resistance

https://x.com/Outdoctrination/status/1995581667281703128?t=6AM_aTeaX7qrf8f1557JvQ&s=33

Emotional

Broken heart

https://t3uncoupled.substack.com/p/dht-heartbreak-and-the-aging-process

Neurological & vestibular

Motion sickness

https://x.com/lowmegatron/status/1995508261601063303?t=Bj736rCCurahDywTLbozhw&s=33

Migraine

Waking lactate tests

Mental

Intrusive thoughts

Vitamin B8 (Inositol)

do yoga about it, get gaba https://pubmed.ncbi.nlm.nih.gov/17532734/

Depression

https://x.com/lowmegatron/status/1991552237630337460?t=fiMVK-upmRpwiOAARmNxsw&s=33

Autism

https://x.com/Outdoctrination/status/1995550210022670672?t=c0T6WAElLM-ksZRfLV86nQ&s=33

ADHD

Problem	Mechanics	Solution	Dose
Vitamin D Deficiency	Significantly lower serum vitamin D levels (19.11±10.10 ng/ml vs. 28.67±13.76 ng/ml in controls)impacting dopaminergic pathways and neuroprotection	Vitamin D supplementation

Brain fog

https://x.com/lowmegatron/status/1995236473612747010?t=P0nrNyc0v0nay6vwZ6oA9A&s=33

Sexual

Inability to climax

"Having an orgasm without enough vitamin E would be like sneezing without first inhaling, the effect is a series of very small, quick sneezes." - Ray Peat

Masters, the sex researcher, recently mentioned that

quite a few women have been losing their ability to have an orgasm after being on the pill for 18 months or longer, and

For certain nerve systems, both taking vitamin E and having an orgasm might be compared to taking a good deep breath.

Tocontinue the analogy between breathing and orgasm. having an orgasm without enough vitamin E would be like sneezing without first inhaling. Some people really do this, and the effect is a series of very small, quick sneezes. That is.

https://archive.org/stream/mega-master-ray-newsletter/MEGA%20Master%20Ray%20Newsletter_djvu.txt

Problem	Mechanics	Solution	Dose

Women problems

Heavy PMS

Have chocolate https://x.com/Helios_Movement/status/1994117410824094060?

B1 for menstrual bleeding https://x.com/Helios_Movement/status/1993978273001255249

PCOS

https://x.com/Helios_Movement/status/1993968780574138678

Chronic Fatigue Syndrome

https://pmc.ncbi.nlm.nih.gov/articles/PMC5869352/

https://x.com/KingOfVitamins/status/1994410164099715497?

Miscariage

https://x.com/Helios_Movement/status/1995061000366596226?t=rlGgbd8cwXH0zQzI0xQwlA&s=33

Early Menarche

Problem	Mechanics	Solution	Dose
Fatherlessness	Not having a father	Get dad	1 father
High PUFA diet
High stress enviroment
Early Menarche Risks	Early menarche (onset <13 years) increases risks of breast cancer, obesity, diabetes, liver disease, depression, eating disorders, substance abuse, and autism in offspring due to elevated estrogen, growth hormone, and prolactin from perceived environmental stress and resource scarcity. Rising tissue iron concentration post-growth cessation exacerbates these risks. (Martinez, 2020 - Lyall et al., 2010 - Villamor et al., 2011 - Barrero et al., 2022 - Zacharias et al., 1964)	Increase progesterone and thyroid levels with a thermogenic diet, reduce environmental stress, and optimize light exposure and vitamin D to delay menarche and extend differentiation.	- Thermogenic diet: Adjust based on individual response (e.g., frequent meals with 50% carbs, moderate protein/fat). - Vitamin D: Sufficient levels to delay by ~1 year (specific dose not quantified, consult health professional). - Light optimization: Natural sunlight exposure, avoid artificial light impairment.
Declining Core Body Temperature	A steady decline in core body temperature since the Industrial Revolution (linked to metabolic slowdown) correlates with earlier menarche, possibly due to reduced thyroid function and increased stress responses, accelerating puberty.	Maximize thermogenicity through diet (e.g., sugars, saturated fats) to boost metabolism and thyroid activity, countering the temperature drop and delaying menarche.	- Thermogenic diet: Start with small amounts (e.g., 1 tsp coconut oil) and build to 1-2 tbsp/day, paired with 200-400g carbs/day from fruits/juice.
Environmental Stress Impact	Stressful, resource-limited environments (e.g., urban vs. rural 17th-19th century data: 17-22 years menarche in peasants vs. 13-15 in townspeople) trigger hormonal shifts (high estrogen/prolactin) to hasten puberty, linked to poor health outcomes. (Tanner (historical data) - Roberton, 1846 - Guarinoni, 1610)	Lower environmental stress by improving light exposure (sunlight vs. artificial), reducing iron overload, and supporting a high-metabolism state to mimic less stressful conditions.	- Light exposure: 15-30 min morning sunlight. - Iron management: Avoid excess (e.g., limit fortified foods), consider donating blood if applicable. - Diet: High progesterone/thyroid foods (milk, eggs).
Light Perception Impairment	Impaired light perception (e.g., in blind individuals) moderately advances menarche by disrupting circadian rhythms and hormonal regulation, increasing estrogen dominance. (Barrero et al., 2022 - Zacharias et al., 1964)	Optimize natural light exposure and minimize artificial light (e.g., blue light at night) to regulate puberty timing via circadian alignment.	- Light optimization: Morning sunlight (10-15 min), blue-light-blocking glasses at night.
Vitamin D Deficiency	Deficiency in vitamin D accelerates menarche, while sufficiency delays it by about one year, likely due to its role in hormonal balance and thyroid support. (Villamor et al., 2011)	Ensure adequate vitamin D intake through diet or sunlight to support delayed menarche and reduce associated disease risks.	- Vitamin D: Sufficient levels (consult health professional for dosing, e.g., 1000-4000 IU/day typical range).

https://x.com/cremieuxrecueil/status/1994650959771820487

Men problems

Infertility

https://x.com/Outdoctrination/status/1995899763246723312

Cancer

General

Problem	Mechanics	Solution	Dose
Cancer-promoting cellular state (e.g., prostate cancer)	Low thyroid function, high estrogen, low CO₂, reduced Mg²⁺/K⁺, and chronic inflammation create a hypoxic, glycolytic, fibrotic environment that disrupts metabolic energy and cell structure.	Restore metabolic energy with T3, sugar, and CO₂; reduce estrogen with progesterone and vitamin E; lower inflammation; re-establish Mg²⁺-ATP-protein-K⁺ structured cell environment.

Don't do keto/low carb or avoid sugar https://pubmed.ncbi.nlm.nih.gov/20818174/ https://www.cancer.columbia.edu/news/study-finds-keto-diet-could-contribute-cancer-metastasis

baking soda https://x.com/lowmegatron/status/1939004757806313497?t=gCCcXmpyIFPvx9MVORA2rw&s=33

haidut protocol https://x.com/Thermobolic/status/1993442981161165055

haidut serotonin https://x.com/haidut/status/1992341840121503769?t=sQaNTtOPL_-jLaFMJUeC8w&s=33

Physical/mechanical damage

Shoulder/joints

Ultrasound therapy

Skin

Eczema

https://x.com/Outdoctrination/status/1995194254835257668?t=6eNhzBcpvkCbazvdSW05QA&s=33

Hair

Androgenic alopecia

More in Hair loss

Grey hair

“I would rub vitamin A and vitamin E (sometimes with DHEA), or a solution of copper acetate, into the skin around the white hairs. Within a few weeks, the bottom of one of the white hairs had begun to darken” - Ray Peat.

Problem	Mechanics	Solution	Dose
Progressive loss of hair pigmentation due to T3 deficiency	low T3 → prolonged telogen phase → reduced melanocyte stem cell activity → decreased melanin transfer to keratinocytes → graying/white hair	Topical or systemic triiodothyronine (T3) → shortens telogen phase → induces early entry into anagen phase → stimulates follicular melanocytes → repigmentation of gray hair Excess or restoration of T3 shortens telogen, stimulates keratinocyte growth, reactivates dormant melanocytes, and restores melanin productionr	Human cases (systemic): • IV T3 + levothyroxine during myxedema coma treatment (T3: 25 μg every 8 h → 12.5 μg every 8 h) • Oral levothyroxine adjustment leading to transient high-normal or elevated T3
Mitochondrial depletion	DGUOK depletion → ROS accumulation → melanocyte stem cell exhaustion	N-acetylcysteine (NAC) to reduce ROS and restore MeSCs	NAC (0.25–2.5 mg/mL in drinking water)
Reduced melanin synthesis due to low thyroid hormone	Thyroid hormone deficiency (low T3) → impaired melanin production in melanocytes	Thyroid hormone T3 to restore melanin synthesis	T3 (adjust to 2.5–5 mcg/day orally, per symptom monitoring)
Oxidative damage to melanocytes	Excess reactive oxygen species (ROS) from poor diet/stress → melanocyte depletion	Vitamin C as an antioxidant to reduce ROS and protect melanocytes	Vitamin C (500–1000 mg/day)
Oxidative stress-induced melanocyte loss	Excess ROS and lipid peroxidation → accelerated melanocyte death	Vitamin E as an antioxidant to mitigate oxidative stress	Vitamin E (200–400 IU/day)
Insufficient micronutrients for melanin production	Low copper/iron from poor diet → reduced tyrosinase activity and melanin synthesis	Nutrient-dense diet (e.g., liver) to supply copper	Liver (100g 2x/week)
Melanin destruction	Severe stress or injected cortisone destroys melanin (causes local or sudden greying)	Oppose excess cortisone by supplementation	Progesterone, pregnenolone, DHEA,
Iron Overload	Iron accumulation with aging + oxygen wastage; iron becomes highly toxic when oxygen is deficient	Greatly reduce dietary iron	Very low-iron diet (mostly milk, cheese, eggs, citrus fruit; very little meat) for several weeks
Copper deficiency	Copper is needed to keep iron non-toxic and for melanin synthesis)	Increase copper intake	Cooked eggs in copper pan daily; topical dilute copper acetate rubbed into skin around white hairs
Excess molybdenum	Displaces copper (turns black sheep’s wool white)	Avoid high molybdenum
Mineral defficiency	Wrong pattern or deficiency of trace minerals (Japanese study: removing all trace minerals → white hair)	Supply the specific trace-mineral pattern associated with the desired color
Youth hormone defficiency	Low pregnenolone/progesterone/DHEA with age or stress	Supplement pregnenolone and DHEA
Oxidative stress	Low antioxidant protection when oxygen is low	High-dose vitamin A (retinol) and vitamin E	Oral: large amounts of preservative-free vitamin A daily Topical: vitamin A + vitamin E (sometimes with DHEA) rubbed around white eyebrow hairs on alternate days

Teeth

more in Dental hygiene

"Teeth that are sensitive to heat or cold suggest a deficiency of calcium, magnesium, or vitamin D." - Ray Peat

Decay

Problem	Mechanics	Solution	Dose
Enamel Demineralization	Sugar + bacteria → acid → demineralization of enamel	Calcium + Vitamin D + Vitamin K2 (to harden enamel)	Calcium (500–1000mg), D3 (1000–2000 IU), K2-MK4 (1–5mg)
Saliva Insufficiency	Saliva buffers pH and delivers minerals; stress and dehydration reduce it	Glycine, hydration, thyroid support	5–10g gelatin (glycine), drink milk, caffeine for stimulation
Low Remineralization / Excess Acid	Frequent snacking, acidic pH, chronic inflammation, fluoride inhibition of thyroid	Baking soda rinse, magnesium, thyroid, avoid PUFA	½ tsp baking soda in water rinse 1–2x/day; Mg (200–400mg)
Bacterial Overgrowth (e.g. Streptococcus mutans)	Biofilm bacteria feed on sugar and produce lactic acid; worsened by immune suppression	Vitamin A, coconut oil (lauric acid), red light	A (5,000–10,000 IU), coconut oil swish (oil pulling) 1 tbsp/day
Weakened Dentin + Collagen Loss	Inflammation, vitamin C deficiency → impaired collagen matrix	Vitamin C, gelatin, copper (lysyl oxidase cofactor)	C (500–1000mg), gelatin 5–10g, shellfish weekly
Tooth Development (children)	Malnutrition during tooth formation → weak enamel, narrow palate	Retinol, calcium, sugar, thyroid support in pregnancy	Retinol-rich liver, dairy, fruit, avoid PUFA in mother

Ears

Ménière's disease

“Hypothyroidism leads to increased estrogen and nitric oxide, and a decreased serum osmolarity (increased dilution of body fluids) and hyponatremia. Salt, magnesium, calcium, aspirin, antihistamine, progesterone, tetracycline (or minocycline, doxycycline) and thyroid can correct the fluid imbalance.” - Ray Peat

Problem	Mechanics	Solution	Dose
High prevalence of hypothyroidism in patients with Ménière’s disease (32% of MD patients vs. 4% of controls	Hypothyroidism contributes to Ménière’s through altered endolymph production or regulation, possibly due to thyroid hormone’s influence on inner ear fluid homeostasis. Thyroid dysfunction could exacerbate or trigger symptoms like vertigo, hearing loss, and tinnitus.	Fix underlying thyroid issues or supplement T3/T4. Salt, magnesium, calcium, aspirin, antihistamines, progesterone and antibiotics.

Misc

Common Cold

Screen addiction

Organs

Heart

High cholesterol

https://x.com/metabolicwave/status/1963989261075546200

Liver

Liver injury

Problem	Mechanics	Solution	Dose
Liver injury symptoms (jaundice, pale feces, dark urine, abdominal pain)	Small-intestinal microbes (fungi/bacteria/parasites) produce toxins → absorbed through permeable small-intestine wall → delivered to liver via hepatic portal system → increases inflammation and liver burden	anti-inflammatory (aspirin) + laxative to clear small intestine (e.g., cascara)	Low-dose aspirin + minimal effective dose of cascara