Minocycline

Minocycline
	[[File:\|250px]]; Chemical structure of minocycline
Formula	C23H27N3O7
Administration	Oral (capsules, tablets, extended-release), intravenous, topical (for acne)
Solubility	Sparingly soluble in water; slightly soluble in ethanol
Legal status	Prescription only
Brand names	Minocin, Solodyn, Dynacin, Ximino, Emrosi, Amzeeq (topical), Zilxi (topical)
Bioavailability	90–100% (oral)
Recommended dose	Infections: 200 mg initially, then 100 mg every 12 hours (adults); 4 mg/kg initially, then 2 mg/kg every 12 hours (children >8 years). Acne: 50–100 mg every 12 hours (immediate-release); 1 mg/kg once daily (extended-release, max 135 mg/day)
Upper limit	400 mg/day (IV); 200 mg/day (oral in renal impairment)
LD50	2380 mg/kg (rat, oral); 3600 mg/kg (mouse, oral)

Introduction

Minocycline
[[File:\|250px]] Chemical structure of minocycline
Formula	C₂₃H₂₇N₃O₇
Administration	Oral (capsules, tablets, extended-release), intravenous, topical (for acne)
Solubility	Sparingly soluble in water; slightly soluble in ethanol
Legal status	Prescription only
Brand names	Minocin, Solodyn, Dynacin, Ximino, Emrosi, Amzeeq (topical), Zilxi (topical)
Bioavailability	90–100% (oral)
Recommended dose	Infections: 200 mg initially, then 100 mg every 12 hours (adults); 4 mg/kg initially, then 2 mg/kg every 12 hours (children >8 years). Acne: 50–100 mg every 12 hours (immediate-release); 1 mg/kg once daily (extended-release, max 135 mg/day)
Upper limit	400 mg/day (IV); 200 mg/day (oral in renal impairment)
LD50	2380 mg/kg (rat, oral); 3600 mg/kg (mouse, oral)