Harm reduction

Recreational drugs and alcohol

Alcohol

Problem	Mechanics	Solution	During	After
Alcohol depletes nutrients, stresses the liver, and increases endotoxin absorption		Avoid Reductive Stress	Fructose + saturated fat (like OJ + coconut oil): Increases alcohol clearance by supporting liver metabolism.	CO2 production: Enhance with thyroid support, red light, and sugar to restore oxidative metabolism.
Chronic use exacerbates oxidative stress and mitochondrial dysfunction.		Copper-rich foods (liver, oysters, shrimp): Protects against alcohol-induced iron overload and mitochondrial dysfunction.	Liver support: Aspirin: Low-dose may reduce fibrosis and inflammation.
Endotoxin- Tumor necrosis factor alpha	Increases endotoxin (LPS), which activates TNF-alpha and IL-6 → inflammation and liver damage, impairs gut microbiota balance, creating dysbiosis	Niacinamide + Thiamine + Lipoic Acid: Supports NAD+/NADH balance and energy production.
Raised estrogen	Beer, wine, and dark whiskey, etc., contain enough estrogen to be harmful.	Pure colorless highly distilled alcohol is the safest
Alcohol metabolism	Acetaldehyde causes toxicity; acetate used for energy or stored as fat, generates free radicals leading to oxidative damage	foods rich in copper, (shellfish), vitamin E against oxidative damage, fructose helps metabolize ethanol faster, aids alcohol metabolism, maintaining effective oxidation of starch and sugar	Vitamin E: Protects against lipid peroxidation (especially if PUFA is present).	Taurine: Liver-protective, helps with bile flow.
foods rich in copper, (shellfish)	increases NADH/NAD+ ratio which impairs energy metabolism.	Activated charcoal: May reduce LPS exposure from gut, especially with meals.	Glycine/Gelatin: Balances methionine, reduces inflammation, supports detox.
PUFA + alcohol + low thyroid = lipid peroxidation (toxic combo).	hypoglycemia with pro-oxidative effect, oxidative reactions between iron and the fats,	Avoid PUFA, (reacts with alcohol, toxic)
thyroid -> mitochondrial respiration	reduces thyroid hormone levels and suppresses mitochondrial respiration
Liver Support
Find and eliminate the need for alcohol.
“The oxidation of alcohol, like that of sugar, depends on the activity of lipoic acid, thiamine, and riboflavin.”

Cigarettes

Problem	Mechanics	Solution	During	After
Increases free fatty acids	Switches from glucose to fatty acid oxidation by increasing FFAs	Niacinamide
Depletes nutrients	Vitamin A, vitamin E,	Take them	Vitamin E: Potent antioxidant, protects against lipid peroxidation from smoke.	Red light therapy: Stimulates cytochrome c oxidase to restore mitochondrial function.
Increases oxidative stress and reduces mitochondrial respiration.	Oxidative stress & lipid peroxidation:		Vitamin C: High doses can counteract oxidative stress and prevent loss of vitamin E.	Progesterone: Anti-inflammatory and stabilizes energy metabolism.
Carbon monoxide	displaces oxygen -> Mitochondrial inhibition		Thyroid hormone (T3 or NDT): Stimulates mitochondrial function and opposes respiratory inhibition.	Avoid PUFA: Smoking + PUFA = highly oxidative combo. Stick to saturated fats (coconut oil, butter).
Nitric oxide	inhibits respiration, inhibit cytochrome oxidase (complex IV), slowing ATP production.		Niacinamide: Supports NAD+ recycling and opposes inflammatory stress.
Various aldehydes	toxic to tissues		Magnesium: Calms overactive stress response
Smoking mold	mycotoxins like aflatoxin for mold-free or organic sources (though quitting is obviously better).		Coffee: Peat often recommended it for stimulating metabolism and aiding heavy metal detox which may reduce some lung cancer risk due to polyphenols.
Ask Travis from beyond the grave
Roll your own American Spirits or organic farm tobacco
Use non-plastic fitlers

Cannabis/Weed/Marijuana

Problem	Mechanics	Solution	During	After
Antiandrogenic or estrogenic	Lowers DHT
Increases prostaglandins
Psychosis risk

Amphetamines/Uppers (Adderall, Ritalin, Meth, Cocaine)

"Excitatory neurotransmitters are always damaging to some degree. The body’s long-term health depends on suppressing these excitotoxic impulses with things like progesterone, CO2, B1, and glucose." "Stimulants that rely on catecholamines are like burning your furniture to stay warm."

Problem	Mechanics	Solution	During	After
Eleveated stress hormones	Stress hormone cascade = PUFA liberation -> ↑ Estrogen .> ↑NO -> ↓ Thyroid -> ↓ Progesterone -> ↑ PUFA liberation	Progesterone, Cyproheptadine or beta blockers, Niacinamide, vitamin C, thyroid, carbs	Progesterone: Neuroprotective, anti-glutamate, reduces stress damage.	Carbohydrates + protein: Especially with gelatin or dairy → replenish neurotransmitters. Avoid fasting/keto: These worsen stress hormone dominance. Progesterone + glycine + honey at bedtime. Endotoxin clearance: Increase dopamine - B6 10mg?, Lucerite
Neuroinflammation	catecholamines -> increased stress and excitotoxic damage to nerve cells	Progesterone, magnesium, pregnenolone, CO2, red light	Magnesium: Calms excitotoxicity, supports energy metabolism.	Brain support: Pregnenolone: Supports GABA, memory, and dopamine function. Thyroid (T3): Helps restore metabolism and dopamine synthesis. Red light therapy: Stimulates mitochondrial repair in neurons. B1 and B3 - neuroprotective, helps burn sugar, every cell uses it
			Niacinamide (B3): Reduces cortisol, stabilizes blood sugar and NAD+ levels.
Dopamine depletion, long-term neurotoxicity.		Increase dopamine - B6 10mg?, Lucerite	Vitamin C: Reduces oxidative stress, supports dopamine and adrenal recovery.	Dopamine repair: Carbohydrates + protein: Especially with gelatin or dairy → replenish neurotransmitters. Avoid fasting/keto: These worsen stress hormone dominance.
Promotes excitotoxicity (glutamate), inflammation, and oxidative stress.
Suppresses appetite, sleep, thyroid, and digestion.				Restore sleep: Progesterone + glycine + honey at bedtime. K2 lowers blood  pressure, vivid dreams, cypro lowers stress hormones
Overdrives sympathetic nervous system	chronic “wired but tired” state. Mind alert, body tired.
Adrenaline spike	crash: Leads to anxiety, paranoia, fatigue, and eventually anhedonia.	Progesterone, thyroid, pregnenolone, stable blood sugar
Thyroid suppression	Long-term use leads to cold hands, fatigue, and low metabolism.	T3 (cytomel), liver, eggs, orange juice
Nutrient depletion	B-vitamins (especially B1, B3, B6), magnesium, zinc, and vitamin C and A are rapidly used up.	Supplement missing nutrients
Uses FFA as fuel	If you're full of PUFA and liberate stores with uppers, causes a lot of the brain damage cases.
Adrenal fatigue, serotonin syndrome	↑ Estrogen -> ↑ Serotonin, makes you take more Uppers, since it lowers serotonin temporarly but ends up raised in the long run - cycle.

https://x.com/ibuybooks/status/1893098215706079627

Cocaine addiction https://x.com/Outdoctrination/status/1789791021737382260?t=ryf3LSrO8zgjwF2n8IWFpw&s=19

lead to addiction by down-regulating the dopamine receptors over time, ultimately causing a lack of motivation for anything but the drug. https://x.com/Outdoctrination/status/1791861395220300267?t=G-cn7M6c8b2a6yiMWc9bFg&s=19

https://x.com/Outdoctrination/status/1978514425780044038?t=wlvecFJUpD00whGsD7MC2Q&s=19

Wait at least 30 minutes before redosing to prevent overdose

Overdose

If severe call ambulance with info - what and how much was taken.

LSD

• B3 syringe helps end trip
• Calm environment
• Assess vitals – Check airway, breathing, circulation; monitor heart rate, BP, temperature.
• Severe hallucinations haloperidol?
• Seizures (rare): Benzodiazepines or anticonvulsants.

Heroin

• 10 mg T3, Narcan blocks opiate receptor

Ecstasy

• Electrolytes

Weed

• Coffee

Cocaine

• Calm down, slow down breathing, bag breathe to prevent hyperventilation
• Don't drink alcohol - mixes into coca ethylene, limits heart valve
• Combo with mdma gives brain damage
• Check for arrhythmia
• Manage hyperthermia - ice packs, fluid, cold bath if extreme
• Half an aspirin if feeling a heart attack coming in the arm, beta blockers, cypro?

Alcohol

• MKUltra 1961 doc claims Cytomel (thyroid hormone T3) sobers from alcohol in 20-30 minutes by oxidizing it?
• Glucose or fructose Prevent/treat hypoglycemia., caffeine - not with high heart rate can mask symptoms could make dehydration worse, could irritate guts and induce vomiting, hydrate, electrolytes
• Make sure the person does not choke on their vomit - fetal position, clear pathway

Prescription drugs

Finnasteride

https://x.com/BowTiedPhys/status/1993692425844334952

Woman

Contraception/Birth control - Progestins/Progestigens/Estrogens

Problem	Mechanics	Solution	During	After
Puts you in the state of menopause/miscarriage
Introduces synthetic estrogens and progestins	Not the same as natural progesterone		Natural progesterone (not progestins): Counteracts estrogen’s inflammatory and stress-promoting effects.	Progesterone: Essential to rebuild healthy ovulatory cycles and reduce estrogen buildup.
Estrogen dominance	Estrogen overloads raise SHBG → lower testosterone → poor libido, energy, mood.	Natural progesterone, thyroid, vitamin E	Thyroid support (T3): Prevents TSH elevation and supports ovary and brain health.
serotonin, cortisol, and nitric oxide.			Vitamin E + Aspirin: Protects against clotting and oxidative damage from estrogen.
Depression, blood clots, weight gain, and infertility	Serotonin increase	Aspirin	Niacinamide + B6 + magnesium: Supports mood, energy metabolism, and dopamine.
Nutrient depletion	B vitamins, magnesium, zinc, and vitamin E.	B-complex, zinc, magnesium, vitamin A & K2		Nutrient repletion: Zinc, B-complex, vitamin A, K2, and magnesium.
Liver burden	Synthetic estrogens strain liver detox pathways, impair bile flow. It cannot detoxify estrogen or endotoxin if doesn't have adequate protein. (60g)	B-complex, Raw carrot, cascara sagrada, activated charcoal		Liver detox: Raw carrots or charcoal: Bind estrogen in the gut and prevent recirculation. Cascara sagrada: Supports bowel motility and estrogen clearance.
Thyroid suppression:	Estrogen raises thyroid-binding globulin → inhibits the release of T4 -> less free T3.
Neurotransmitter distortion	Increases serotonin and decreases dopamine → flat affect, mood issues	Study	Niacinamide, pregnenolone, sugar, animal protein
Suppresses natural hormone production	Especially ovulation, progesterone, and thyroid.	Get off of it you harlot		Support ovulation: Saturated fat, cholesterol, protein, carbs (e.g. liver, eggs, dairy, OJ). Avoid PUFA, stress, and fasting   these suppress ovulation.
Infertility	Sky high estrogen + serotonin	Saturated fat, carbs, liver, red light, thyroid, progesterone, aspirin, cypro, vitamin D & E,
Makes women bisexual	Skews healthy sexual attraction	Repent
Outgroup preference, infidelity, ruined ability to pairbond	Seeking degen novelty
Inability to experience fear correctly, numbness, pain tollerance, disgust treshold	Dangerous, self destructive behavior, violent/disgusting kinks	Progesterone, salt
Attracted to imcompatible males	Inability to smell them T3 article	Thyroid
It's a carcinogen	Certain oral contraceptives are classified as carcinogens by the World Health Organization's International Agency for Research on Cancer (IARC),
Window for conception is limited to a few days a month, there is no need to be on it all the time, for Peat's sake use a condom.
PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP PLAP GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT GET PREGNANT

PED/Hormone abuse

Gear/Steroids/PEDs - supraphysiological amounts

View testosterone as metabolic, not purely anabolic: It’s downstream of thyroid and progesterone.

Balance hormones via liver function first: Estrogen is cleared by the liver - burdened livers = estrogen buildup.

Progesterone is pro-libido, anti-estrogen, is protective on tissue, organ and cell level - helps reverse many steroid side effects.

Progesterone, unlike testosterone, doesn’t aromatise and thus doesn't contribute to baldness or aggressive behavior, and it opposes estrogen’s growth-promoting and inflammatory effects.

Problem	Mechanics	Solution	During	After
Suppresses endogenous testosterone & DHT	Leads to erectile dysfunction, depression, poor wound healing.	Post Cycle Therapy - restore hormone production - progesterone, thyroid, lot of aspirin and pregnenolone for AI,		Restore hormones Progesterone: Natural HPTA booster, lowers estrogen, reduces anxiety. DHEA or pregnenolone: Supports neurosteroids and testosterone production. Thyroid (T3 or NDT): Enhances DHT/testosterone synthesis.
Estrogen dominance via aromatization	Puffiness, mood swings, inflammation,		Aromatase inhibition: Progesterone + DHEA: Natural aromatase inhibitor, anti-estrogenic, balances anabolic signaling. Pregnenolone: Pro-androgenic, anti-stress. Thyroid (T3): Supports liver detox and prevents estrogen buildup.
Nitric oxide and vascular permeability	vascular leakage, “pump” sensation, and tissue damage, raised inflammation, veiny vehind palms		Nitric oxide suppression: Vitamin B1 (thiamine) and niacinamide reduce NO levels. Methylene blue (low dose): Peat-favored for inhibiting nitric oxide and supporting mitochondria.
Disrupts collagen integrity	skin, hair, libido, mood.
with low thyroid function worsens side effects.
PUFA + steroids = bad	amplify estrogenic and inflammatory effects of steroids.
Aromatisation	water retention, gynecomastia, vascular leakage	progesterone, pregnenolone, and thyroid hormone
liver burden, fibrosis	especially oral AAS, Due to increased oxidative stress, cholestasis, and endotoxin from gut.	saturated fats	Liver protection: Saturated fats: Protective against fibrosis Vitamin K2 + taurine + glycine: Help with bile flow and collagen integrity.
Cholesterol level fluctuate	Low cholesterol makes you feel like death, supresses immune system and youth hormone production	Check cholesterol level esp when taking T3

https://x.com/pikeypilled/status/1995528302543401093?t=m-iiBZLb0pKHRPAVV3L9Jg&s=33

Sports

Weight Cutting / Dehydration / Making Weight

Problem	Mechanics	Solution	During	After
Rapid water and weight loss	Extreme stress on the body.		Electrolyte balance: Prioritize sodium + potassium over just water restriction.	Rehydrate with sodium + sugar: Orange juice with salt is ideal.
Elevates cortisol, adrenaline, aldosterone, and serotonin	Suppresses thyroid and immune function	Niacinamide, progesterone, sugar, gelatin, magnesium	Carbohydrates: Avoid ketosis; use juice, milk, honey to fuel liver and preserve muscle.	Thyroid (T3): If metabolic markers are low (cold hands, fatigue, low pulse).
Nutrient and CO2 depletion	Depletes sodium, potassium, glycogen, reduces CO₂ production	Balance of electrolytes, particularly sodium and potassium	Niacinamide: Prevents excessive lipolysis and cortisol.	Progesterone: For men and women - restores GABA, lowers stress, increases DHT and testosterone.
Hormonal suppression	Testosterone and thyroid = loss of libido, mood crashes, and inflammation.	T3, cholesterol-rich foods, red light, liver	Gelatin + sugar: Calms nerves, lowers serotonin, and supports sleep.	Red light therapy: Helps repair skin, joints, and mitochondria.
Hypothyroid, inflamed states after cut		Salt, potassium, OJ, milk, baking soda	Caffeine with sugar/salt: Safer stimulant to maintain energy without wrecking thyroid.	Saturated fats + cholesterol: Rebuild hormone synthesis (liver, eggs, butter, dairy).
Dehydration / electrolyte imbalance	↑ Aldosterone (water retention rebound), ↓ Blood volume, ↑ Cortisol			Electrolytes, rehydrate, IV in extreme cases, check urine color. Avoid PUFA: Exacerbates stress damage.
Caloric deficit	↓ Thyroid, ↓ Progesterone, ↑ Estrogen dominance	Carrot salad, progest-E, vitamin B6, cascara
Salt restriction	Stress hormones, ↓ Nerve conductivity, ↓ CO₂
Glycogen depletion	↓ Brain function, ↑ Fatigue, ↓ Mood
Sleep disruption / fatigue
Risk of brain damage	Thirsting (dehydration) for 16hrs resulted in 0.55% decrease in brain volume, increase traumatic brain injury (TBI)
	impairing blood flow, brain function, and the body's ability to regulate temperature,
Sugar drop makes blood brain barrier permeable	Allows toxins to enter the brain

Long distance running

https://www.runnersworld.com/health-injuries/a39445076/thyroid-disease/

https://x.com/lowmegatron/status/1995598857476968910?t=IzX2wZBlM8rL8s9uC4HCmA&s=33

Toxin exposure

Heavy metals

https://x.com/Outdoctrination/status/1866212036964683799?t=gf8HBHVQfIbt07hb8J7BKA&s=33

Tattoo

https://x.com/zerohedge/status/1994923117265801222?t=NY12yinpiUgDlVl-GfcdTQ&s=33

Fluoride

https://x.com/lowmegatron/status/1988320911104086445