Coffee

Coffee is a vitamin.

“B1 and coffee can make a tremendous difference if you want to sit down and memorize. I did it over a weekend with plenty of coffee and vitamin B1. I just sat down and memorized 4,000 words in French” - Ray Peat

"Giving rats the human equivalent dose of 3500 mg/day has no harmful effects, even when continued for several generations. One study found no harmful effects when rats were fed large amounts of caffeine for up to three and a half years. Since lab rats rarely live that long, I think caffeine's effects on longevity should be investigated." - Ray Peat

"We never drink plain water, and if you make coffee with city water, that’s one of the practical ways of filtering it. Heavy metals are very efficiently bound to the coffee grounds if you make the drip method coffee, so that you put in dirty water and you get clean coffee.” - Ray Peat

Ray Peat's Coffee

https://x.com/5HTskeptic/status/1880208737098686813

Benefits
Protects the liver	Helps guard against damage from alcohol, acetaminophen, and other toxins.
Cancer protection	Reduces risk of cancers caused by radiation, chemicals, viruses, and estrogens.
Supports hormone balance	Synergizes with progesterone and increases its concentration in blood and tissues.
Protective against breast cancer	Associated with lower incidence of breast cancer.
Nutrient source	Provides magnesium and small amounts of other nutrients, including vitamin B1 (thiamine).
Boosts energy metabolism	Improves efficiency of fuel use and supports TCA cycle activity (better mitochondrial energy production).
Enhances performance	Increases stamina, alertness, and physical/mental performance.
Mental health support	Coffee drinkers show a lower incidence of depression and suicide. The risk of depression drops 8% per cup of coffee. The risk of depression decreases at 68 mg of caffeine/day. The risk gets progressively lower up to 500 mg/day.
Detox support	Acts as a chelator of certain heavy metals (e.g., cadmium).
Neuroprotection	Helps prevent nerve cell death and reduces risk of Parkinson’s disease.

Benefits

Caffeine increases glucose availability even when carbohydrate intake is very low.

https://x.com/HeightOptimized/status/1994298413983420701

Coffee rapidly lowers prolactin.

“Prolactin concentrations significantly decreased after consumption.”"

“Chronic pretreatment with caffeine for 14 days and for 10 days during stress reversed the avoidance of social behavior and anhedonia induced by social defeat stress in mice, suggesting the enhancement of the resilience to social defeat stress induced by caffeine.”

Cancer prevention

https://x.com/lowmegatron/status/1993696314958234054?t=On4V-XMB7El14DBVDzBfSA&s=33

Telemetre lenght

"3-4 cups of coffee daily is associated with longer telomeres in people with severe mental disorders"

"The difference was comparable to ~5 years younger biological age versus non-drinkers"

Not getting enough sleep increases pain sensitivity.

Caffeine reduces pain sensitivity.

“Sleep quality and duration predict presence of pain the next day in healthy subjects, suggesting that sleep disturbances alone may worsen pain, and experimental sleep deprivation in humans... Caffeine and modafinil, two wake-promoting agents that have no analgesic activity in rested mice, immediately normalize pain sensitivity in sleep-deprived animals, without affecting sleep debt.”

“Individuals who habitually consume greater amounts of caffeine as part of their daily diets demonstrate diminished sensitivity to painful stimuli in a laboratory setting.”

Obviously, you don’t want to dose caffeine in such a way that it interferes with sleep...

Acrylamide levels

Chart: Average acrylamide levels in selected coffees (in parts per billion, or ppb)

Brand	Not instant	Instant	Dark Roast	Regular Roast	Brewed
Folgers	314	458	237	346	10
Maxwell House	215	218	201	223	6
Chock full o’Nuts	201	N/A	191	212	N/A
Starbucks	149	N/A	132	158	9
Hills Bros	135	N/A	N/A	135	N/A
Yuban	51	N/A	N/A	51	N/A
Café Bustelo	142	N/A	138	N/A	6
Medaglia D’Oro	168	N/A	164	N/A	6
Taster’s Choice	272	353	N/A	N/A	7
Nescafé	N/A	471	N/A	N/A	6
7-Eleven	N/A	N/A	N/A	N/A	6