| Naturally produced and released by the adrenal medulla (chromaffin cells)
Small amounts also synthesized in certain neurons in the central nervous system
Biosynthesis pathway: L-Tyrosine → L-DOPA → Dopamine → Norepinephrine → Epinephrine (final step catalyzed by phenylethanolamine N-methyltransferase, PNMT)
Medicinal/commercial source: synthetic or formerly extracted from animal adrenal glands
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